Tuning T cell activation threshold and effector function with cross-reactive peptide ligands
نویسندگان
چکیده
منابع مشابه
Tuning T cell activation threshold and effector function with cross-reactive peptide ligands.
We have generated a panel of cross-reactive T cells by immunizing SJL mice (I-A(s)) with Q144 peptide, an analog of an autoantigenic peptide (W144) of myelin proteolipid protein (PLP) 139-151 (HSLGKWLGHPDKF) in which W was replaced by Q at position 144. Following immunization with Q144, T cells were expanded in vitro with W144, which is a cross-reactive, suboptimal ligand, for Q144-specific T c...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2000
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/12.2.205